Dr. Ye Zheng’s recent work, RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples, is accepted by Science!

Congratulations to Ye Zheng for publishing a co-first author paper in Science!

This study leverages the FFPE-CUTAC epigenomic profiling method for mapping RNA Polymerase II (RNAPII) genome-wide in formalin-fixed paraffin-embedded (FFPE) sections. We found that elevated RNAPII at histone genes in meningiomas and diverse breast cancers is consistent with histone production being rate-limiting for S-phase progression and histone gene hypertranscription driving overproliferation and aneuploidy in cancer, with general implications for precision oncology. Please refer to the Project page (link to this project) for more details.

For more details about this research, please visit our Publications section.