Article-Journal

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer

The development and function of stem and progenitor cells that produce blood cells are vital in physiology. GATA-binding protein 2 …

Soukup AA, Zheng Y , Mehta C, Liu P, Hofmann I, Zhou Y, Zhang J, Choi K, Johnson KD, Keles S, Bresnick EH

GATA/Heme Multi-omics Reveals a Trace Metal-dependent Cellular Differentiation Mechanism

By functioning as an enzyme cofactor, hemoglobin component, and gene regulator, heme is vital for life. One mode of heme-regulated …

Tanimura N, Liao R, Wilson GM, Dent MR, Cao M, Burstyn JN, Hematti P, Liu X, Zhang Y, Zheng Y , Keleş S, Xu J, Coon J, Bresnick E

Perm-seq: Mapping Protein-DNA Interactions in Segmental Duplication and Highly Repetitive Regions of Genomes with Prior-enhanced Read Mapping

Segmental duplications and other highly repetitive regions of genomes contribute significantly to cells’ regulatory programs. …

Zeng X, Li B, Welch R, Rojo C, Zheng Y , Dewey CN, Keleş S