Clinical Applications

RNA Polymerase II at histone genes predicts outcome in human cancer

We demonstrate that RNA Polymerase II occupancy at histone genes, measured by FFPE-CUTAC, serves as a powerful predictor of cancer outcomes and enables efficient tumor classification.

Henikoff S, Zheng Y , Paranal R, Xu Y, Greene J, Henikoff J, Russell Z, Szulzewsky F, Thirimanne H, Kugel S, Holland E, Ahmad K

Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion

Chimeric antigen receptor-modified T cell (CAR-T) immunotherapy has revolutionised blood cancer treatment. Parsing the genetic …

Fiorenza S, Zheng Y , Purushe J, Bock T, Sarthy J, Janssens D, Sheih A, Kimble E, Kirchmeier D, Phi T, Gauthier J, Hirayama A, Riddell S, Wu Q, Gottardo R, Maloney D, Yang J, Henikoff S, Turtle C