Epigenetics

Histone Methylation Mark Analyses Distinguish Carts Manufactured from Distinct Sources and Uncover Novel Transcription Factors Associated with In Vivo Function of Carts after Infusion into DLBCL Patients That Are Not Identified By RNA-Seq

Chimeric antigen receptor-modified T cell (CART) therapy has heralded a revolution in cancer immunotherapy. Yet, understanding the …

Fiorenza S, Zheng Y , Sarthy J, Sheih A, Kimble E, Kirchmeier D, Janssens D, Phi T, Gauthier J, Hirayama A, Wu Q, Gottardo R, Riddell S, Maloney D, Henikoff S, Turtle C

Single-cell CUTTag analysis of chromatin modifications in differentiation and tumor progression

Methods for quantifying gene expression1 and chromatin accessibility2 in single cells are well established, but single-cell analysis of …

Wu S, Furlan S, Mihalas A, Kaya-Okur H, Feroze H, Emerson S, Zheng Y , Carson K, Cimino P, Keene C, Holland E, Sarthy J, Gottardo R, Ahmad K, Henikoff S, Patel A

Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models

Background: Diffuse midline gliomas (DMGs), including diffuse intrinsic pontine gliomas (DIPGs), have a dismal prognosis, with less …

Vitanza N, Biery M, Myers C, Ferguson E, Zheng Y , Girard E, Przystal J, Park G, Noll A, Pakiam F, Winter C, Morris S, Sarthy J, Cole B, Leary S, Crane C, Lieberman N, Mueller S, Nazarian J, Gottardo R, Brusniak M, Mhyre A, Olson J