Gene Regulation

Regulatory architecture of the RCA gene cluster captures an intragenic TAD boundary and enhancer elements in B cells

The Regulators of Complement Activation (RCA) gene cluster comprises several tandemly arranged genes with shared functions within the …

Cheng J, Clayton J, Acemel R, Zheng Y , Taylor R, Keles S, Harley J, Quail E, Gómez-Skarmeta J, Ulgiati D

Discovering How Heme Controls Genome Function Through Heme-omics

Protein ensembles control genome function by establishing, maintaining, and deconstructing cell-type-specific chromosomal landscapes. A …

Liao R, Zheng Y , Liu X, Zhang Y, Seim G, Tanimura N, Wilson G, Hematti P, Coon J, Fan J, Xu J, Keleş S, Bresnick E

Expanded Encyclopedias of DNA Elements in the Human and Mouse Genomes

The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context …

The ENCODE Project Consortium, Admin

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer

The development and function of stem and progenitor cells that produce blood cells are vital in physiology. GATA-binding protein 2 …

Soukup AA, Zheng Y , Mehta C, Liu P, Hofmann I, Zhou Y, Zhang J, Choi K, Johnson KD, Keles S, Bresnick EH