Hi-C

High-throughput genome-wide chromatin conformation capture assay (Hi-C) is routinely used to profile long-range genomic interactions …

High-fidelity Hi-C data simulation pipeline using Fragment Interactions Empirical Estimation method

Python pipeline for simulating differential chromatin interactions with data-driven or user-specified spike-ins

The ability to simulate high-throughput chromatin conformation (Hi-C) data is foundational for benchmarking Hi-C data analysis methods. …

Robust Hi-C analysis pipeline incorporating multi-mapping reads through probabilistic assignment

Current Hi-C analysis approaches are unable to account for reads that align to multiple locations, and hence underestimate biological …