Multi-Mapping Reads

Generative modeling of multi-mapping reads with mHi-C advances analysis of Hi-C studies

Current Hi-C analysis approaches are unable to account for reads that align to multiple locations, and hence underestimate biological …

Zheng Y , Ay F, Keleş S

Perm-seq: Mapping Protein-DNA Interactions in Segmental Duplication and Highly Repetitive Regions of Genomes with Prior-enhanced Read Mapping

Segmental duplications and other highly repetitive regions of genomes contribute significantly to cells’ regulatory programs. …

Zeng X, Li B, Welch R, Rojo C, Zheng Y , Dewey CN, Keleş S